Brilinta Oral inhibits blood platelets from clumping together and blocking an artery.
Thank you for reading this post, don't forget to subscribe!Brilinta reduces the risk of heart attack, stroke, or death from a blocked artery or previous heart attack.
If you have coronary artery disease and have had stents to open clogged arteries, Brilinta reduces the risk of blood clots.
Brilinta reduces the risk of a first heart attack or stroke in people with poor cardiac blood flow.
Brilinta reduces the incidence of stroke and death in persons with brain artery blockages.
Usually administered with low-dose aspirin. Follow your doctor’s dosage. Aspirin can reduce ticagrelor’s efficacy.
You can also read Benzonatate: (Oral Route) Drug Information
Brilinta Oral mechanism of action
Directly inhibiting ADP receptor activity is the job of the active metabolites of thienopyridines. Ticagrelor binds to a location on the P2Y12 receptor that is separate from the one where ADP normally binds.
BRILINTA is able to bind to the ADP P2Y12 receptor in a way that is reversible, thereby blocking the binding of ADP to the receptor. This stops the signal transduction and platelet activation that could otherwise result in the creation of a pathological thrombus.
Ticagrelor is able to redistribute to newly generated platelets thanks to the reversible binding that occurs between it and platelets.
There is a lack of understanding on the relationship between clinical efficacy and safety and pharmacology or chemical class.
It has not been possible to conduct adequate head-to-head clinical trials that compare BRILINTA and thienopyridines in patients with acute ischemic stroke or high-risk coronary artery disease who have not previously suffered from a heart attack or stroke.
Metabolism and the kinetics of drugs
Brilinta has a maximal concentration after 1.5 hours and a bioavailability of around 36%. An estimated 99 percent of brilinta and its active metabolite are linked to proteins in the blood.
CYP3A4 is the primary enzyme in metabolism. The parent medication has a half-life of around 7 hours, whereas the active metabolite has a half-life of around 9 hours. Hepatic metabolism and biliary excretion are the primary routes of elimination.
Brilinta Oral drug warnings:
If you have brain or stomach bleeding, do not use Brilinta. Avoid using this medication before heart bypass surgery (coronary artery bypass graft, or CABG).
To prevent severe bleeding, you may need to temporarily cease using this prescription before surgery or dental work. Even if you’re bleeding, consult your doctor before stopping Brilinta. Stopping this medication may raise heart attack and stroke risk.
Brilinta may induce severe or fatal bleeding. Avoid risky behaviors.
Continual bleeding requires medical treatment. Your stomach or intestines may bleed. If you cough up blood or vomit coffee grounds, call your doctor. These may indicate internal hemorrhage.
If used with Brilinta, several drugs—including some over-the-counter and herbal ones—can cause major health issues. Telling your doctor about recent medications is crucial.
Brilinta Oral Pre-medication:
If you have:
- active bleeding;
- brain bleeding history (such as from a head injury).
- stroke
- heart issues;
- cholesterol;
- bleeding;
- stomach ulcers or colon polyps;
- hepatitis
- dialysis;
- asthma, COPD, or other breathing issues;
- major surgery or injuries;
- before surgery or dental work;
What effect on Pregnant women?
The safety of Brilinta use during pregnancy has not been established. Fetuses harmed when pregnant females were administered Brilinta in animal tests. However, results from animal tests don’t necessarily translate to humans.
You should discuss taking Brilinta with your doctor if you are pregnant or planning to get pregnant. They’ll talk to you about the pros and cons of the treatment.
Combining Brilinta with other methods of contraception ( Birth control)
Safety of Brilinta use during pregnancy has not been established. Talk to your doctor about your options for birth control while taking Brilinta if you or your sexual partner are able to become pregnant.
Combining Brilinta with nursing (breastfeeding)
While taking Brilinta, breastfeeding is not advised. It has been established in animal research that Brilinta can be found in the breast milk of breastfeeding mothers. However, it is important to remember that results from animal experiments don’t necessarily translate to human subjects.
It is recommended that you see your physician before to taking Brilinta if you are breastfeeding. They may provide you advice on how to feed your kid in a way that is both healthy and secure.
Brilinta Oral dosage—how?
Take Brilinta as directed. Read and follow all medication recommendations and prescription labels. Brilinta with aspirin.
Follow these instructions.
Take only aspirin prescribed by your doctor. Aspirin can reduce Brilinta’s efficacy.
Take this drug daily, with or without meals.
Crush and combine pills to swallow them. Mix and drink immediately. Stir and sip additional water.
Brilinta prevents blood coagulation, making even slight injuries easier to bleed. Continual bleeding requires medical treatment.
Before surgery, medical or dental work, Brilinta may need to be stopped to prevent severe bleeding. Your doctor should know you take ticagrelor.
Even if you’re bleeding, consult your doctor before stopping Brilinta. Stopping the medication may increase your heart attack and stroke risk.
- Store: dry and cool.
Dosage of Brilinta Oral
Acute Coronary Syndrome Dose:
- 180 mg orally.
- The maintenance dose is 90 milligrams to be taken orally twice a day for a period of one year.
- Maintenance dose: 60 mg twice a day.
Comments:
- This medication should be used along with daily doses of oral aspirin ranging from 75 to 100 mg.
- This medication outperforms clopidogrel for 12 months after ACS.
Uses: To minimize cardiovascular mortality, myocardial infarction, and stroke in individuals with acute coronary syndrome (ACS) or a history of MI.
To decrease stent thrombosis in ACS stented patients.
Atherothrombotic Event Prevention Dose:
After ACS:
- 180 mg orally.
- The maintenance dose is 90 milligrams to be taken orally twice day for a period of one year.
- Maintenance dose: 60 mg twice a day.
Comments:
- This medication should be used along with daily doses of oral aspirin ranging from 75 to 100 mg.
- This medication outperforms clopidogrel for 12 months after ACS.
Uses: To minimize cardiovascular mortality, myocardial infarction, and stroke in individuals with acute coronary syndrome (ACS) or a history of MI.
To decrease stent thrombosis in ACS stented patients.
Adult Thromboembolic Stroke Prevention Dose:
- Twice-daily 60 mg oral.
Use: To lower the incidence of a first myocardial infarction (MI) or stroke in high-risk patients with coronary artery disease (CAD). This medicine was shown to be effective in type 2 diabetes patients (T2DM).
Normal Adult Coronary Artery Disease Dose:
- Twice-daily 60 mg oral.
Use: To lower the incidence of a first myocardial infarction (MI) or stroke in high-risk individuals with coronary artery disease (CAD). This medicine was found to be effective in type 2 diabetic patients (T2DM).
Myocardial infarction Prophylaxis:
- Twice-daily 60 mg oral.
Use: To lower the incidence of a first myocardial infarction (MI) or stroke in high-risk individuals with coronary artery disease (CAD). This medicine was found to be effective in type 2 diabetic patients (T2DM).
Missed doses—what happens?
Skip the missed dose and take your next dose on time. Avoid double-dosing.
Overdosing—what happens?
Call 911 or Poison Help at 1-800-222-1222. Overdose causes bleeding.
When we avoid Brilinta Oral?
Aspirin and alcohol might cause gastrointestinal bleeding.
Avoid risky behaviors and bleeding while shaving or cleaning your teeth.
Avoid discomfort, fever, swelling, and cold/flu medications while using Brilinta with aspirin. Aspirin-like compounds are possible (such as salicylates, ibuprofen, ketoprofen, or naproxen). Aspirin overdose from certain products can increase bleeding risk.
Brilinta side effects
In the event that you develop hives, difficulty breathing or swelling in your face, lips, tongue, or neck, you should dial 911 immediately.
- heartburn;
- fainting;
- unstoppable nosebleeds;
- shortness of breath even when resting or exercising;
- bruising, bleeding, purple or red skin patches;
- crimson, pink, or brown urine;
- dark, bloody, or tarry stools;
- vomiting coffee-colored blood or vomit.
Common Brilinta side effects:
- Bleeding
- Breathlessness
Other side effects may arise. Side effects? Call your doctor. Call 1-800-FDA-1088 to report side effects.
What medications interact with Brilinta?
Combining drugs can be dangerous. Some pharmaceuticals can alter the blood levels of other drugs, increasing negative effects or decreasing efficacy.
Inform your doctor of all medications. Brilinta interacts with many medications, including:
- antifungal drugs (ketoconazole, itraconazole, voriconazole, etc.);
- antibiotics (including clarithromycin);
- HIV/AIDS antivirals;
- blood thinners;
- cholesterol medications like simvastatin or lovastatin;
- heart/blood pressure medication
- opioids;
- anticonvulsants
- TB medication rifampin
Many more medicines may effect Brilinta. Vitamins, herbs, and prescription and over-the-counter medications are included. Drug interactions are not listed here.
FAQs
Frequent Inquiries Regarding Brilinta
Some queries about Brilinta have been answered below.
1. What exactly does Brilinta do to the blood? Does it thin the blood or prevent clotting?
The answer is yes, Brilinta is a blood thinner. It’s a medication that prevents platelets from clumping together and clotting. Platelets are clumping cells responsible for clotting blood. So Brilinta aids in keeping your blood thin and clot-free by preventing the activation of the cells.
It’s important to note that Brilinta is not an anticoagulant. In contrast to antiplatelets, anticoagulants prevent blood from clotting. Anticoagulants function on different proteins that aid in blood clotting than platelets do. The blood proteins that are affected by various anticoagulants vary. Anticoagulants work by slowing down the blood clotting process.
How Brilinta works is explained in greater detail below in the “How Brilinta works” section.
2. Does caffeine assist Brilinta-induced shortness of breath?
Caffeine may or may not aid in the alleviation of Brilinta-induced dyspnea. One clinical trial indicated that persons using Brilinta who also consumed coffee did not see any improvement in their shortness of breath. The study did discover, however, that most Brilinta users could safely consume coffee.
Stop taking Brilinta and see your doctor if you have shortness of breath. They may have suggestions for lowering the risk of this occurrence.
3. When taking Brilinta, should I limit any certain foods?
Intake of grapefruit or grapefruit juice while taking Brilinta may raise your risk of bleeding complications. Because grapefruit inhibits the enzyme responsible for breaking down Brilinta, the drug builds up in your system and becomes more potent.
Brilinta’s efficacy, on the other hand, is unaffected by what you eat. The antiplatelet medication Brilinta is distinct from the anticoagulant medicine warfarin.
Foods high in vitamin K may reduce the efficacy of anticoagulant medications. Foods like leafy greens fall under this category. That is not the case, however, with antiplatelet medications such as Brilinta.
Consult your physician for advice on how to eat healthfully while taking Brilinta.
4. Am I supposed to stop taking Brilinta before my surgery?
Maybe, however, it really depends on what kind of operation you’re having.
Stop taking Brilinta at least 5 days before surgery if you’re undergoing surgery with a high risk of bleeding, such as stomach surgery. Consequently, your platelets can resume their normal functions. Following surgery, your platelets will assist keep the blood from clotting too quickly and will avoid further bleeding. Your surgeon will let you know when you can resume Brilinta treatment.
You may be able to continue taking Brilinta without a pause if your upcoming surgery does not provide a significant risk for bleeding.
If you are taking Brilinta and are scheduled for surgery, make sure your doctors and nurses are aware of this. In cases where discontinuation of the drug is necessary, your doctor or healthcare team will advise you on how long to wait.
Ask your doctor if you can take Brilinta closer to your upcoming surgery.
5. Is it safe to combine Brilinta and Tylenol?
Tylenol (acetaminophen) is generally safe to consume with Brilinta. Get advice from your doctor or pharmacist before self-medicating with a pain reliever like Tylenol. They will be able to tell you if it’s safe for you to take the drug.
6. Will I experience Brilinta withdrawal if I suddenly stop using it?
For Brilinta, there are no withdrawal symptoms that have been documented.
In order for your platelets to return to their pre-Brilinta levels of function, it will take many days after you stop taking the medication. Platelets are specialized cells in your blood that aid in clotting. However, this process does not produce any noticeable symptoms.
Do not stop taking Brilinta without first consulting your doctor. Taking such measures can raise the danger of having a heart attack, stroke, or blood clot. The precise risk to you is related to your specific therapeutic goal. Your doctor may advise you to discontinue use after the first year. The length of time you should take Brilinta will be specified.
Tell your doctor if you experience any strange side effects after discontinuing Brilinta. They will evaluate your condition to determine the root of your symptoms and provide treatment suggestions if required.
7. Can I use omeprazole or another medicine for GERD in addition to Brilinta?
Probably, that’s the case. Omeprazole (Prilosec OTC) is a proton pump inhibitor used for the treatment of acid reflux.
Those who suffer from acid reflux and take Brilinta can also take omeprazole without any adverse effects. There are no known drug interactions between Brilinta and proton pump inhibitors.
Consult a medical professional if you suffer from acid indigestion. They’ll give you advice on what they think is the most effective course of treatment.