Aspirin tablet uses is a salicylate it works by reducing substances in the body that cause pain,Β fever, or inflammation.
Thank you for reading this post, don't forget to subscribe!Aspirin is used to treatment for pain, and reduce fever or inflammation. It is sometimes used to treatment or prevent heart attacks,Β strokes, and chest pain like (angina).
Only under the supervision of a doctor aspirin should be used for cardiovascular conditions.
Class : ( Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics) ) , ( Nonsteroidal Anti-inflammatory Drugs (NSAIDs) )
Mechanism of action aspirin:
Aspirin is an analgesic, anti-inflammatory and antipyretic. It inhibits cyclooxygenase, which is responsible for the synthesis of prostaglandin and thromboxane. It also inhibits platelet aggregation. Duration: 4-6 hr.
Absorption: Rapidly absorbed from the GI tract (oral); less reliable (rectal); absorbed through the skin (topical). Peak plasma
concentrations after 1-2 hr.
Distribution: Widely distributed; crosses the placenta; enters breast milk. Protein-binding: 80-90%.
Metabolism: Hepatic; converted to metabolites.
Excretion: Via urine by glomerular filtration, active renal tubular secretion and passive tubular reabsorption (as unchanged drug); via haemodialysis; 15-20 minutes (elimination half-life, parent drug).
Related aspirin information:
Indication & Dosage of Oral aspirin tablet uses:
Prophylaxis of myocardial infarction:
- Adult:Β Aspirin 75-325 mg once daily and lower doses should be used in patients receiving ACE inhibitors.
Stent implantation:
- For adult: 325 mg aspirin 2 hour before procedure followed by 160-325 mg/day thereafter.
Aspirin tablet uses in juvenile rheumatoid arthritis:
- Use for child: Aspirin 80-100 mg/kg daily in 5 or 6 divided doses and up to 130 mg/kg daily in acute exacerbations if necessary.
Mild to moderate pain and fever:
- Adult use aspirin: 325-650 mg repeated every 4-6 hour according to response or max: 4 g/day. May also be given rectally.
Max Dosage of aspirin in other condition like:
Pain and inflammation associated with musculoskeletal and joint disorders.
- Adult use: Initial: 2.4-3.6 g/day in divided doses or usual maintenance: 3.6-5.4 g/day. Monitor serum concentrations.
How to take aspirin?
Aspirin should be taken with food.
Side effect of aspirin:
- GI disturbances;
- prolonged bleeding time,
- rhinitis,
- urticaria and
- epigastric discomfort;
- angioedema,
- salicylism,
- tinnitus;
- bronchospasm.
Potentially Fatal:
- Gastric erosion
- Ulceration and bleeding
- Occasionally fatal exacerbation of airway obstruction in asthma
- Reye’s syndrome (children <12 year)
- Hepatotoxicity
- CNS depression which may lead to coma
- CV collapse and respiratory failure
- Paroxysmal bronchospasm and dyspnoea
Over dosage of aspirin:
Symptoms may include:
- Hyperventilation
- Fever
- Restlessness
- Ketosis
- Respiratory alkalosis and metabolic acidosis
- CNS depression may lead to coma;
- CV collapse and respiratory failure.
- In children, drowsiness and metabolic acidosis commonly occur
- Hypoglycaemia
Contraindications of aspirin:
- Gout
- Hypersensitivity (attacks of asthma, angioedema, urticaria or rhinitis)
- Active peptic ulceration
- Pregnancy (3rd trimester)
- Children <12 yr, patients with haemophilia or haemorrhagic disorders
- Severe renal impairment
- Hepatic impairment
- Lactation
Special Precautions:
- History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion
- Asthma
- Allergic disorders
- Dehydrated
- Patients, uncontrolled hypertension
- Impaired renal or hepatic function
- Elderly
Drug Interactions:
- Alcohol,
- corticosteroids,
- analgin
- phenylbutazone and oxyphenbutazone may increase risk of GI ulceration.
- Aspirin increases phenytoin levels or may antagonize actions of uricosurics and spironolactone.
Potentially Fatal: May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.
Food Interaction: Vitamin-rich foods increase urinary excretion.
Lab Interference: Interferes with thyroid function tests.
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