Only under the supervision of a doctor aspirin should be used for cardiovascular conditions.
Class : ( Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics) ) , ( Nonsteroidal Anti-inflammatory Drugs (NSAIDs) )
Mechanism of action aspirin:
Aspirin is an analgesic, anti-inflammatory and antipyretic. It inhibits cyclooxygenase, which is responsible for the synthesis of prostaglandin and thromboxane. It also inhibits platelet aggregation. Duration: 4-6 hr.
Absorption: Rapidly absorbed from the GI tract (oral); less reliable (rectal); absorbed through the skin (topical). Peak plasma
concentrations after 1-2 hr.
Distribution: Widely distributed; crosses the placenta; enters breast milk. Protein-binding: 80-90%.
Metabolism: Hepatic; converted to metabolites.
Excretion: Via urine by glomerular filtration, active renal tubular secretion and passive tubular reabsorption (as unchanged drug); via haemodialysis; 15-20 minutes (elimination half-life, parent drug).
Related aspirin information:
Indication & Dosage of Oral aspirin tablet uses:
Prophylaxis of myocardial infarction:
- Adult: Aspirin 75-325 mg once daily and lower doses should be used in patients receiving ACE inhibitors.
- For adult: 325 mg aspirin 2 hour before procedure followed by 160-325 mg/day thereafter.
Aspirin tablet uses in juvenile rheumatoid arthritis:
- Use for child: Aspirin 80-100 mg/kg daily in 5 or 6 divided doses and up to 130 mg/kg daily in acute exacerbations if necessary.
Mild to moderate pain and fever:
- Adult use aspirin: 325-650 mg repeated every 4-6 hour according to response or max: 4 g/day. May also be given rectally.
Max Dosage of aspirin in other condition like:
Pain and inflammation associated with musculoskeletal and joint disorders.
- Adult use: Initial: 2.4-3.6 g/day in divided doses or usual maintenance: 3.6-5.4 g/day. Monitor serum concentrations.
How to take aspirin?
Aspirin should be taken with food.
Side effect of aspirin:
- GI disturbances;
- prolonged bleeding time,
- urticaria and
- epigastric discomfort;
- Gastric erosion
- Ulceration and bleeding
- Occasionally fatal exacerbation of airway obstruction in asthma
- Reye’s syndrome (children <12 year)
- CNS depression which may lead to coma
- CV collapse and respiratory failure
- Paroxysmal bronchospasm and dyspnoea
Over dosage of aspirin:
Symptoms may include:
- Respiratory alkalosis and metabolic acidosis
- CNS depression may lead to coma;
- CV collapse and respiratory failure.
- In children, drowsiness and metabolic acidosis commonly occur
Contraindications of aspirin:
- Hypersensitivity (attacks of asthma, angioedema, urticaria or rhinitis)
- Active peptic ulceration
- Pregnancy (3rd trimester)
- Children <12 yr, patients with haemophilia or haemorrhagic disorders
- Severe renal impairment
- Hepatic impairment
- History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion
- Allergic disorders
- Patients, uncontrolled hypertension
- Impaired renal or hepatic function
- phenylbutazone and oxyphenbutazone may increase risk of GI ulceration.
- Aspirin increases phenytoin levels or may antagonize actions of uricosurics and spironolactone.
Potentially Fatal: May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.
Food Interaction: Vitamin-rich foods increase urinary excretion.
Lab Interference: Interferes with thyroid function tests.