Amlodipine Tablet class: (Calcium Antagonists) , ( Anti-Anginal Drugs ) amlodipine
Thank you for reading this post, don't forget to subscribe!Relevant information regarding amlodipine
Angina pectoris, hypertension of the oral cavity, and Prinzmetal’s angina
- Adults: should start with 5 mg once a day and work their way up to 10 mg once daily if it’s needed.
- Elderly: The recommended starting dose is 2.5 mg taken once daily.
- Impairment of the liver: Initial dosage is 2.5 milligrams taken once daily.
Administration: Amlodipine Tablet
Take the medication either with or without food.
Overdosage: Amlodipine Tablet
An overdose has the potential to cause significant peripheral vasodilation as well as hypotension.
Contraindications:
Hypersensitivity to dihydropyridines is well documented.
Special Precautions:
Inadequate function of the liver or kidneys, congestive heart failure, sick sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, and severe aortic stenosis are all potential risk factors. Patients who have idiopathic hypertrophic subaortic stenosis should be treated with caution when using this medication. children and the elderly Pregnancy, as well as breastfeeding
Reactions Unfavorable to Drugs:
Headache, peripheral edema, lethargy, somnolence, nausea, abdominal pain, flushing, dyspepsia, palpitations, and dizziness are some of the symptoms that may be experienced. Pruritus, rash, dyspnea, asthenia, and muscle cramps have been reported very rarely. Hypotension, bradycardia, conductive system delay, and congestive heart failure all have the potential to be fatal.
Interactions Between Drugs:
Rifampin causes a speeding up of the metabolic process. Calcium has a dampening influence on the hypotensive response. The effects of thiazide diuretics and ACE inhibitors are amplified by this compound. Patients who have significantly reduced left ventricular function should avoid taking beta-blockers in combination with other medications. It is possible that serum concentrations of CYP1A2 substrates, such as aminophylline, fluvoxamine, and ropinirole, would rise. There is a possibility that CYP3A4 inhibitors, such as clarithromycin, doxycycline, isoniazid, and nicardipine, could amplify the effects of amlodipine. Effects on blood pressure that are additive when combined with sildenafil, tadalafil, or vardenafil.
US Food and Drug Administration Pregnancy Category C:
Either research conducted on animals has shown that the substance has harmful effects on the developing fetus (teratogenic, embryocidal, or other), but there have been no controlled studies conducted on pregnant women, or neither studies involving pregnant women nor animals have been conducted. Only if the possible benefit justifies the potential risk to the fetus may pharmaceuticals be administered during pregnancy.
Storage: Amlodipine Tablet
Maintain a temperature between 15 and 30 degrees Celsius when storing.
The Workings of the Mechanism:
Amlodipine has the ability to relax the smooth muscle of the coronary and peripheral blood vessels.
It does this by preventing calcium ions from entering voltage-sensitive channels in vascular smooth muscle and heart when the cells are in a depolarized state. This results in coronary vasodilation.
In patients who have vasospastic angina, it also raises the amount of oxygen that is delivered to the myocardium.
- Absorption: Very good absorption from the gastrointestinal system (orally); peak plasma concentrations after six to twelve hours.
- Distribution: Protein-binding: 97.5%. Hepatic metabolism is a significant contributor.
Elimination occurs primarily in the form of metabolites, with just 10% remaining unchanged; the elimination half-life ranges from 35-50 hours.
Conclusion: Amlodipine Tablet
Amlodipine Class: (Calcium Antagonists), (Anti-Anginal Drugs) amlodipine relevant information regarding amlodipine. Angina pectoris, hypertension of the oral cavity, and Prinzmetal’s anginaAdults should start with 5 mg once a day and work their way up to 10 mg once daily if it’s needed.
Elderly: The recommended starting dose is 2.5 mg taken once daily.
Impairment of the liver: Initial dosage is 2.5 milligrams taken once daily.
AdministrationTake the medication either with or without food.
Overdosage An overdose has the potential to cause significant peripheral vasodilation as well as hypotension.
Contraindications hypersensitivity to dihydropyridines is well documented.
Special Precautions Inadequate function of the liver or kidneys, congestive heart failure, sick sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, and severe aortic stenosis are all potential risk factors.
Adults should start with 5 mg once a day and work their way up to 10 mg once daily if it’s needed. The recommended starting dose is 2.5 mg taken once daily for children and the elderly.
There have been no controlled studies conducted on pregnant women or animals to determine their effects on the fetus.
There is a possibility that CYP3A4 inhibitors, such as clarithromycin, doxycycline, isoniazid, and nicardipine, could amplify the effects of amlodipine.