Aceclofenac
Thank you for reading this post, don't forget to subscribe!Class of drug: (Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Nonsteroidal Anti-inflammatory Drugs are those which reduce pain in fever inflammation and blood clotting.
Aceclofenac is a potent inhibitor of cyclo-oxygenase which is involveing in the production of prostaglandins. Side effects of the drug are diarrhea, vomiting, rash, and others also. For adults, 100mg can be taken twice a day.
Take this medicine only as per a doctor’s prescription or pharmacist’s advice.
Mechanism of action aceclofenac:
Aceclofenac is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Absorption: Well, absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr.
Distribution: Protein-binding: 99%.
Excretion: Urine (as hydroxy metabolites); 4 hr (elimination half-life).
Indication & dosage of aceclofenac:
Drugs are using in this condition if you have Ankylosing spondylitis, Rheumatoid arthritis, or Osteoarthritis.
Aceclofenac dose in adults: 100 mg bid ( Two time in a day)
If you have a problem like Hepatic impairment: Reduce the initial dose to 100 mg daily.
Hou to take the aceclofenac:
This drug is taken with food and you can also take it immediately after food.
Adverse drug reactions of aceclofenac:
- Diarrhea
- Nausea
- Dyspepsia
- Abdominal pain
- Dizziness
- Rashes
- Increased LFTs.
If a person has such a problem, then medicine cannot be given because it can increase the chances of death like.
- Severe GI bleeding
- Nephrotoxicity
- Blood dyscrasias.
If you have these signs and symptoms after taking medicine, then contact your doctor immediately. and stop taking this medicine
Contraindications:
If you ever have this kind of disease, then you cannot take this medicine.
- Hypersensitivity to aspirin or NSAIDs
- Moderate to severe renal impairment
- Pregnancy (3rd trimester)
- History of peptic ulceration or GI bleed
- Patients with infections.
Overdosage:
If an overdose occurs due to drug taking in a person, then it can be manage in this way
- Gastric lavage and treatment with activated charcoal.
- Treatment is supportive and symptomatic.
- Dialysis,
- Hemoperfusion is unlikely to be useful.
Special Precautions:
There are some special conditions in which this medicine cannot be taken. If the medicine is taken in this condition, then it can be life threatening.
- Cautiously administer to patients with GI disease
- Ulcerative colitis
- Crohn’s disease
- Hematological abnormalities
- Hepatic porphyria
- History of bronchial asthma
- History of heart failure or hypertension
- Mild renal impairment
- Hepatic impairment
- Cardiac impairment
- May impair the ability to drive or operate machinery.
Drug Interactions:
- It May increase plasma concentrations of lithium and digoxin.
- Increased nephrotoxicity when used with diuretics or ciclosporin.
- Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors.
- May enhance the activity of anticoagulants.
- May increase the risk of methotrexate toxicity when administered within 24 hr of methotrexate admin.
- Increased risk of GI bleeds with other NSAIDs.
- Increased risk of convulsion with quinolones.