Drugs & Supplement

Aceclofenac Paracetamol Use Doses

June 18, 2022
drprit
Aceclofenac paracetamol
Class of drug: ( Analgesics (Non-Opioid) & Antipyretics ) , ( Nonsteroidal Anti-inflammatory Drugs (NSAIDs) )
Aceclofenac Paracetamol this a drug use for pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
we can take drugs with food or without food. An adult dose is 200 mg per day. There are no any data for children before 18 yr don’t give medicine without prescription. in elder persons who have to suffer from impaired renal, cardiovascular or hepatic function and receiving concomitant medication, the chance increases serious risk.
Swallow the tablet whole glass with water don’t crash and break. continue to take tablets as doctor’s advice. if you miss the dose don’t take 2 tablets at the time continue as regular.
Aceclofenac + paracetamol tablets for reducing pain and inflammation.
Adult: Each tablet contains aceclofenac 100 mg and paracetamol 500 mg. Max: 2 tablets/day
Symptoms like:
  • Headache
  • Nausea,
  • Vomiting,
  • Epigastric pain,
  • Gastrointestinal irritation,
  • Gastrointestinal bleeding,
  • Rarely diarrhea,
  • Disorientation,
  • Excitation,
  • Coma,
  • Drowsiness,
  • Dizziness,
  • Tinnitus,
  • Hypotension,
  • Respiratory
  • Depression,
  • Fainting,
  • Some tome symptom like convulsions.
This medicine can cause renal failure and liver damage (hepatic toxicity).
If you have any symptoms due to overdose call emergency immediately in India (108).

Contraindications aceclofenac paracetamol:

If you have this type of disease can not take Aceclofenac + paracetamol. Cannot give this medicine in all these conditions.
  • Hypersensitivity
  • Moderate to severe renal impairment
  • Hepatic impairment
  • Severe heart failure
  • Pregnancy (third trimester).
Special Precautions aceclofenac paracetamol:
You can not consume this type of medicine without a doctor’s advice if you have a disease like:
  • GI disease.
  • Renal or hepatic impairment.
  • Alcohol-dependent patients.
  • Asthma or allergic disorders.
  • Hemorrhagic disorders.
  • Hypertension.
  • Cardiac impairment.
  • Elderly.
  • Pregnancy.
  • Lactation.
  • Caution when driving or operating machinery.
  • Check renal and hepatic function and blood counts during long-term treatment.
  • Elevated hepatic enzyme levels may need drug withdrawal.

Side effect:

Paracetamol:
  • Nausea,
  • Allergic reactions,
  • Skin rashes,
  • Acute
  • Renal tubular necrosis.
Aceclofenac:
  • Diarrhea,
  • Headache,
  • Vertigo,
  • Dizzies,
  • Nervousness,
  • Tinnitus,
  • Depression,
  • Drowsiness,
  • Insomnia;
  • Fever,
  • Angioedema,
  • Bronchospasm,
  • Rashes;
  • Blood dyscrasias.
By taking this medicine, all these diseases occur in the body, due to which death can also occur
  • Paracetamol: Very rare, blood dyscrasias (eg, thrombocytopenia, leucopenia, neutropenia, agranulocytosis), liver damage.
  • Aceclofenac: Severe GI bleeding, nephrotoxicity.

Drug Interactions:

Aceclofenac and paracetamol interact with other drugs
  • Cholestyramine: Absorption decreases due to Paracetamol.
  • Metoclopramide: Absorption increases if we take paracetamol.
  • Lithium and Digoxin: Plasm concentration increases due to Aceclofenac.
  • Diuretics: Increase nephrotoxicity. ( When we use potassium-sparing diuretic we should check Serum-potassium level.).
  • Anticoagulants: This drug increases the property of anticoagulants.
  • Methotrexate:Β Methotrexate in plasma will increase and cause toxicity.
  • Quinolones: There is an increased chance of convulsion.
Paracetamol in chronic alcoholics conditions increases the chance of liver damage.
Increase toxicity due to overdose and long time taking.
And because of taking all these medicines for a long time.
  • Barbiturates,
  • Carbamazepine,
  • Hydantoins,
  • Isoniazid,
  • Rifampin,
  • Sulfinpyrazone.

Mechanism of Action:

Aceclofenac inhibits the synthesis of the inflammatory cytokines interleukin-1b and tumor necrosis factor. And inhibits prostaglandin E2 production.
Aceclofenac increases glycosaminoglycans (GAG) synthesis. it helps the regeneration of articular cartilage.
Paracetamol has both action analgesic and antipyretic it has weak anti-inflammatory activity. The action of the hypothalamus reduces pain and fever.
  • Aceclofenac: Fast almost 100% absorbing in blood.
  • Bioavailability:Β  Peak plasma concentration about 1.25-3 hr after oral admin.
  • Distribution: Aceclofenac: Is distribution into the synovial fluid. More than 99.7% bind to plasma proteins.
  • Metabolism: Aceclofenac: It is metabolism by CYP2C9. Half-life: is 4-4.3 hr.
  • Excretion: Aceclofenac: is excreting via urine, as conjugated hydroxy metabolites.
  • Paracetamol: PCM distributes throughout most fluids of the body.
  • Paracetamol: Paracetamol is metabolizes by the liver; plasma elimination half-life: 1-4 hr.
  • Paracetamol: Whatever metabolizes paracetamol gets passed out from the urine within 24 hours.

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